GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6759004 | 1 | rs6759004 | chr2:202004676 | NIF3L1 | chr2:201754050-201768655:+ | -0.25 | -3.48 | 0.000556 | Triptolide cytotoxicity |
| THCA | cis | rs6759004 | 1 | rs6759004 | chr2:202004676 | PPIL3 | chr2:201735680-201753999:- | -0.91 | -16.45 | 1.62E-48 | Triptolide cytotoxicity |
| THCA | cis | rs4664308 | 1 | rs6759836 | chr2:160912802 | LY75 | chr2:160625141-160761262:- | 0.21 | 4.81 | 2.0E-6 | Idiopathic membranous nephropathy |
| THCA | cis | rs4664308 | 1 | rs6759924 | chr2:160912747 | LY75 | chr2:160625141-160761262:- | 0.23 | 5.34 | 1.48E-7 | Idiopathic membranous nephropathy |
| THCA | cis | rs2941509 | 1 | rs67600807 | chr17:38001559 | C17orf37 | chr17:37885411-37886788:- | -0.28 | -4.58 | 5.85E-6 | Systemic lupus erythematosus |
| THCA | cis | rs589756 | 1 | rs676056 | chr6:132642659 | MOXD1 | chr6:132617195-132722664:- | 0.27 | 4.67 | 3.96E-6 | Obesity-related traits |
| THCA | cis | rs13014235 | 1 | rs6761514 | chr2:202227549 | ALS2CR12 | chr2:202153148-202222101:- | -0.38 | -7.57 | 1.91E-13 | Basal cell carcinoma |
| THCA | cis | rs13014235 | 1 | rs6761514 | chr2:202227549 | PPIL3 | chr2:201735680-201753999:- | -0.24 | -5.03 | 6.95E-7 | Basal cell carcinoma |
| THCA | cis | rs10935120 | 1 | rs6763088 | chr3:134254989 | ANAPC13 | chr3:134196547-134204865:- | -0.39 | -12.14 | 9.6E-30 | Height |
| THCA | cis | rs10935120 | 1 | rs6763088 | chr3:134254989 | CEP63 | chr3:134204575-134293852:+ | -0.31 | -6.6 | 1.07E-10 | Height |
| THCA | cis | rs10935120 | 1 | rs6763093 | chr3:134254995 | ANAPC13 | chr3:134196547-134204865:- | -0.39 | -12.14 | 9.6E-30 | Height |
| THCA | cis | rs10935120 | 1 | rs6763093 | chr3:134254995 | CEP63 | chr3:134204575-134293852:+ | -0.31 | -6.6 | 1.07E-10 | Height |
| THCA | cis | rs1075232 | 1 | rs67634762 | chr15:31748055 | FAM7A2 | chr15:30864758-30892900:+ | -0.39 | -3.6 | 0.000349 | Survival in colorectal cancer (non-distant metastatic) |
| THCA | cis | rs9815354 | 1 | rs6763829 | chr3:41897046 | ULK4 | chr3:41288091-42003660:- | 1.09 | 20.95 | 1.23E-69 | Diastolic blood pressure |
| THCA | cis | rs730532 | 1 | rs67640320 | chr14:52511596 | NID2 | chr14:52471521-52535946:- | -0.19 | -4.04 | 6.25E-5 | Pulmonary function |